
梁森,中国科学院过程工程研究所,生化工程国家重点实验室,副研究员,硕士生导师。主要从事凝胶生物材料的设计、制备及其在生物医用领域的应用。
教育经历2015.09-2020.06 中国科学院大学/中国科学院理化技术研究所,材料学,工学博士
2009.09-2013.06 兰州大学,化学(基地班),理学学士
工作经历2024.10-至今 中国科学院过程工程研究所/生化工程国家重点实验室,副研究员
2022.07-2024.10 中国科学院过程工程研究所/生化工程国家重点实验室,助理研究员
2020.07-2022.07 中国科学院过程工程研究所/生化工程国家重点实验室,特别研究助理
2013.07-2015.07 中国核工业集团,助理工程师
科研项目主持国家自然科学基青年项目(30万)1项,重要参与中国科学院基础与交叉前沿科研先导专项(2030万)、高水平医院临床业务费专项成果转化项目(50万)、国家自然科学基金面上项目(54万、62万)、重要应用项目(横向,300万)等5项,总经费2526万元。
(1)短肽自组装构筑可注射温敏荧光水凝胶及在肿瘤电外科手术中的应用(主持)
(2)高效人机接口与单分子感知器件(重要参与)
(3)新型可注射水凝胶用于消化道瘘封堵剂的研发(技术负责人)
(4)3D打印肽自组装导电水凝胶定向支架用于骨骼肌修复的应用研究(重要参与)
(5)用于单细胞温度检测的硅纳米线传感器及其能量转移过程研究(重要参与)
(6)具有自粘附、导电、透明凝胶电极研发和量产工艺开发(骨干成员)
论文及专著
1. Chaoyue Gu*†; Fanzhen, Kong†; Sen, Liang*†; Zhao, Xiang; Kong, Bingjie; Jiang, Tianhe; Yu, Jianan; Li, Qi; Yuqing, Lin†; Shuo, Bai†; Yuanhua, Shao, In vivo dynamic tracking of cerebral chloride regulation using molecularly tailored liquid/liquid interfacial ultramicro iontronics. Science Advances 10 (49): eadr7218.
2. Sen Liang†; Yajie, Tian†; Bai, Shuo*, Peptide-based Hydrogels for Soft Electronic Devices and Wearable Biosensors. In Peptide Self‐Assembly and Engineering, 2024; pp 393-419.
3. Sen Liang; Wang, Yuan; Wu, Xueke; Chen, Min; Mu, Lixuan*; She, Guangwei; Shi, Wensheng*, An ultrasensitive ratiometric fluorescent thermometer based on frustrated static excimers in the physiological temperature range. Chemical Communications 2019, 55 (24): 3509-3512.
4. Sen Liang; Wang, Yuan; Mu, Lixuan*; She, Guangwei; Shi, Wensheng*, Robust liquid-core nanocapsules as biocompatible and precise ratiometric fluorescent thermometers for living cells. Nanotechnology 2020, 31 (36): 365502.
5. Linna Hao; Sen Liang; Han, Qingquan; Jing, Yafeng; Li, Jieling; Li, Qi; Wang, Anhe; Bai, Shuo; Yin, Jian, Ultralong hydroxyapatite nanowires-incorporated dipeptide hydrogel with enhanced mechanical strength and superior in vivo osteogenesis activity. Colloids and Surfaces A: Physicochemical and Engineering Aspects 2023, 664: 131153.
6. Yuan Wang; Sen Liang; Mei, Mingliang; Zhao, Qiaowen; She, Guangwei; Shi, Wensheng*; Mu, Lixuan, Sensitive and Stable Thermometer Based on the Long Fluorescence Lifetime of Au Nanoclusters for Mitochondria. Analytical Chemistry 2021, 93 (45): 15072-15079.
7. Dongdong Liu; Yin, Jiaxiang; Sen Liang; Shi, Wensheng; Jiang, Xingyu; Gao, Yuan*, Enzyme-Regulated Peptide-Liquid Metal Hybrid Hydrogels as Cell Amber for Single-Cell Manipulation. ACS Applied Materials & Interfaces 2020, 12 (41): 45807-45813.
8. Mingliang Mei; Mu, Lixuan*; Sen Liang; Wang, Yuan; She, Guangwei; Shi, Wensheng*, A general configurational strategy to quencher-free aptasensors. Biosensors and Bioelectronics 2021, 178: 113025.
9. Yuan Wang; Zhao, Qiaowen; Sen Liang; Mei, Mingliang; She, Guangwei; Shi, Wensheng*; Mu, Lixuan*, Single nanowire-based fluorescence lifetime thermometer for simultaneous measurement of intra- and extra-cellular temperatures. Chemical Communications 2023, 59 (30): 4483-4486.
10. Mingliang Mei; Mu, Lixuan*; Wang, Yuan; Sen Liang; Zhao, Qiaowen; Huang, Lushan; She, Guangwei; Shi, Wensheng*, Simultaneous Monitoring of the Adenosine Triphosphate Levels in the Cytoplasm and Nucleus of a Single Cell with a Single Nanowire-Based Fluorescent Biosensor. Analytical Chemistry 2022, 94 (34): 11813-11820.
11. Xueke Wu; Mu, Lixuan*; Chen, Min; Sen Liang; Wang, Yuan; She, Guangwei; Shi, Wensheng*, Bifunctional Gold Nanobipyramids for Photothermal Therapy and Temperature Monitoring. ACS Applied Bio Materials 2019, 2 (6): 2668-2675.
12. Linna Hao; Wang, Anhe; Fu, Junjie; Sen Liang; Han, Qingquan; Jing, Yafeng; Li, Jieling; Li, Qi; Bai, Shuo*; Seeberger, Peter H.; Yin, Jian*, Biomineralized dipeptide self-assembled hydrogel with ultrahigh mechanical strength and osteoinductivity for bone regeneration. Colloids and Surfaces A: Physicochemical and Engineering Aspects 2023, 657: 130622.
13. Qi Li; Wang, Anhe; Li, Jieling; Sen Liang; Tian, Yajie; Bai, Shuo*, A synergistic therapy strategy for hypoxic solid tumor therapy. Matter 2022, 5 (8): 2425-2428.
14. Xingxing Cao; Mu, Lixuan; Chen, Min; Bu, Congcong; Sen Liang; She, Guangwei; Shi, Wensheng*, Single Silicon Nanowire-Based Fluorescent Sensor for Endogenous Hypochlorite in an Individual Cell. Advanced Biosystems 2018, 2 (12): 1800213.
15. Min Chen; Mu, Lixuan; Wang, Shuai; Cao, Xingxing; Sen Liang; Wang, Yuan; She, Guangwei; Yang, Jun; Wang, Yongan; Shi, Wensheng*, A Single Silicon Nanowire-Based Ratiometric Biosensor for Ca2+ at Various Locations in a Neuron. ACS Chemical Neuroscience 2020, 11 (9): 1283-1290.
专利
1. 白硕, 梁森, 李靖涛, 张祎. 一种体温引发成型的水凝胶敷料及其制备方法. 中国发明专利, 授权号: ZL 202210930294.2.
2. 李靖涛, 白硕, 梁森, 张祎. 一种温敏可注射抗菌水凝胶填充物及其制备方法. 中国发明专利, 授权号: ZL 202210972202.7.
3. 李靖涛, 白硕, 梁森, 张祎. 一种可注射抗菌堵瘘水凝胶及其制备方法. 中国发明专利, 授权号: ZL 202310389638.8.
4. 白硕, 李靖涛, 梁森, 张祎. 一种可注射止血防黏连水凝胶及其制备方法. 中国发明专利, 授权号: ZL 202310424788.8.
5. 师文生,梁森,穆丽璇. 一种荧光比率式共聚高分子温度计及其制备与应用. 中国发明专利, 授权号: ZL 202010249916.6.
6. 李靖涛, 白硕, 梁森, 张祎. 一种透明质酸-三肽分子静电共组装可注射水凝胶及其制备方法. 中国发明专利, 申请号: 202410788058.0(实质审查中)
7. 顾超越,梁森,白硕. 一种用于实时监测氯离子的超微电极及其制备与应用. 中国发明专利, 申请号: 2024106385196(实质审查中)